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A Case of Lacrimal Gland Ductal Carcinoma With Regional Lymph Node Metastasis

Everett, Lesley A. M.D., Ph.D.; Copperman, Thomas S. M.D.; Kersten, Robert C. M.D.

Ophthalmic Plastic & Reconstructive Surgery: September/October 2019 - Volume 35 - Issue 5 - p e118–e121
doi: 10.1097/IOP.0000000000001447
Case Reports

Ductal carcinoma of the lacrimal gland is a very rare and aggressive neoplasm, with clinical and histopathologic similarities to salivary ductal carcinoma. Of the 25 previously reported cases, 2 patients had metastases to local lymph nodes confirmed on pathologic examination. The authors now report the clinical presentation, histopathologic and immunohistochemical features, and the treatment of a third patient with lacrimal gland ductal carcinoma with spread to local lymph nodes. In contrast to ductal carcinoma, lymph node involvement has not been reported in the largest series of adenoid cystic carcinoma, a much more common lacrimal gland malignancy. This case highlights the need for possible lymph node surveillance in patients with lacrimal gland ductal carcinoma.

This patient represents the third reported case of lacrimal gland ductal adenocarcinoma with regional lymph node metastasis, suggesting that lymph node surveillance should be considered for patients with this rare neoplasm.

Department of Ophthalmology, University of California San Francisco, San Francisco, California, U.S.A.

Accepted for publication June 21, 2019.

The authors have no financial or conflicts of interest to disclose.

Address correspondence and reprint requests to Thomas S. Copperman, M.D., Department of Ophthalmology, University of California San Francisco, 10 Koret Way, San Francisco, CA 94143. E-mail:

© 2019 by The American Society of Ophthalmic Plastic and Reconstructive Surgery, Inc., All rights reserved.