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Lacrimal Gland Orbital Lobe Cysts Associated With Lymphoid Hyperplasia or Mucosa-Associated Lymphoid Tissue Lymphoma in Patients With Chronic Autoimmune Disease

Dutton, Alice E., M.B.B.S.*; McElnea, Elizabeth M., F.R.C. Ophth.*; Rubinstein, Tal J., M.D.; Curragh, David S., F.R.C. Ophth.; McKelvie, Penny A., F.R.P.C.A.§; Selva, Dinesh, F.R.A.C.S., F.R.A.N.Z.C.O.; Rose, Geoffrey E., F.R.C. Ophth.; McNab, Alan A., F.R.A.N.Z.C.O.*

Ophthalmic Plastic & Reconstructive Surgery: May/June 2019 - Volume 35 - Issue 3 - p e59–e62
doi: 10.1097/IOP.0000000000001344
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Large cysts in the orbital lobe of the lacrimal gland are rare and are associated with Sjögren syndrome and B-cell mucosa-associated lymphoid tissue lymphoma. The authors describe 4 new cases of large orbital lobe lacrimal gland cysts. The first 2 patients, both with Sjögren syndrome, had unilateral cysts associated with chronic inflammation. Mucosa-associated lymphoid tissue lymphoma was also identified in the cyst wall of the second case and could not be completely excluded in the first case. The third patient, with a history of rheumatoid arthritis, had bilateral cysts, again associated with mucosa-associated lymphoid tissue lymphoma. The fourth patient, with no history of systemic disease, had a unilateral cyst associated with reactive lymphoid hyperplasia. Finally, the authors report the long-term outcomes of 3 previously reported cases.

In patients with chronic autoimmune disease, cysts of the orbital lobe of the lacrimal gland may be associated with lymphoid hyperplasia or mucosa-associated lymphoid tissue lymphoma.

*The Royal Victorian Eye and Ear Hospital, Melbourne, Victoria, Australia

Moorfields Eye Hospital, London, United Kingdom

Royal Adelaide Hospital, Adelaide, South Australia, Australia

§St Vincent’s Hospital, Melbourne, Victoria, Australia

Accepted for publication January 26, 2019.

The authors have no financial or conflicts of interest to disclose.

This manuscript was produced in compliance with the Declaration of Helsinki.

Address correspondence and reprint requests to Alice E. Dutton, M.B.B.S., The Royal Victorian Eye and Ear Hospital, 32 Gisborne Street, Melbourne, VIC, 3002, Australia. E-mail: alicedutton@hotmail.com

© 2019 by The American Society of Ophthalmic Plastic and Reconstructive Surgery, Inc., All rights reserved.