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Triamcinolone for the Treatment of Graves Ophthalmopathy Tested With Short Tau Inversion Recovery Magnetic Resonance

Ortiz-Basso, Tomás, M.D., M.S.*; Vigo, Rodolfo L., M.D.*; Sidelnik, Mariano, M.D.; Vazquez-Durand, Mariana S., M.D., M.S.; Shokida, María F., M.D.*; Prémoli, Eduardo J., M.D.*; García-Mónaco, Ricardo, M.D.

Ophthalmic Plastic & Reconstructive Surgery: January/February 2019 - Volume 35 - Issue 1 - p 22–24
doi: 10.1097/IOP.0000000000001125
Original Investigations
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Purpose: To evaluate if parabulbar triamcinolone reduces orbital swelling in patients with Graves ophthalmopathy.

Methods: This is a prospective study of a series of patients with active and moderate Graves ophthalmopathy. Short tau inversion recovery magnetic resonance was used to evaluate the intensity of the extraocular rectus muscles and orbital fat, before and after the treatment with parabulbar triamcinolone.

Results: The signal intensity ratio of the sum of the OD rectus muscles was 3.67 before treatment (95% CI, 3.26–4.09) and 2.83 after treatment (95% CI, 2.63–3.03) (p < 0.001), and of the muscles of the left orbit, 3.94 before treatment (95% CI, 3.50–4.38) and 2.85 after treatment (95% CI, 2.56–3.14) (p < 0.001). The signal intensity ratio of the fat decreased from 2.95 (95% CI, 2.69–3.21) to 2.33 (95% CI, 2.07–2.58) (p < 0.001). After treatment, there were no local or systemic complications.

Conclusion: The use of parabulbar triamcinolone reduces orbital inflammation of patients with active and moderate Graves ophthalmopathy.

Parabulbar triamcinolone decreases the signal intensity ratio of extraocular muscles and orbital fat in patients with active Graves ophthalmopathy.

*Department of Ophthalmology

Department of Diagnostic Imaging, Hospital Italiano de Buenos Aires, Buenos Aires, Argentina

Accepted for publication March 9, 2018.

The authors have no financial or conflicts of interest to disclose.

Presented, in part, as a hot topic poster at The Association for Research in Vision and Ophthalmology Annual Meeting on May 1–5, 2016 in Seattle, WA.

Address correspondence and reprint requests to Tomás Ortiz-Basso, M.D., M.S., Department of Ophthalmology, Hospital Italiano de Buenos Aires, Juan Domingo Perón 4190, Buenos Aires C1199ABB, Argentina. E-mail: tomas.ortiz@hospitalitaliano.org.ar

© 2019 by The American Society of Ophthalmic Plastic and Reconstructive Surgery, Inc., All rights reserved.