Brief ReportsAutosomal Dominant Early Onset Aponeurotic Ptosis and Corneal Limbal Vascularization in a Three-generation FamilyIsmail, Andre R. F.R.C.Ophth.*; Cates, Carolyn A. F.R.C.Ophth.*; Mullins, Robert F. Ph.D.†; Manners, Ruth M. F.R.C.S., F.R.C.Ophth.*; Lotery, Andrew J. M.D., F.R.C.Ophth.*‡Author Information *Southampton Eye Unit and ‡University of Southampton, Southampton, United Kingdom; †Department of Ophthalmology and Visual Sciences, University of Iowa, Iowa City, IA, U.S.A. Accepted for publication March 21, 2007. Supported, in part, by Research Management Committee, Southampton, United Kingdom. The authors have no proprietary interest. Presented, in part, at the Annual Meeting of the Association for Research in Vision and Ophthalmology, Fort Lauderdale, Florida, U.S.A., April 25–29, 2004. Address correspondence and reprint requests to Prof. A.J. Lotery, Southampton Eye Unit, Tremona Road, Southampton SO16 6YD United Kingdom; E-mail: firstname.lastname@example.org Ophthalmic Plastic & Reconstructive Surgery: November-December 2007 - Volume 23 - Issue 6 - p 484-486 doi: 10.1097/IOP.0b013e318157d3f9 Buy Metrics AbstractIn Brief A novel phenotype in a 3-generation family with early-onset aponeurotic ptosis and corneal limbal vascularization is described. Karyotype analysis was normal in the proband, and autosomal dominant transmission is demonstrated. A novel phenotype of early onset aponeurotic ptosis and corneal limbal vascularization segregating in a three-generation family is described. ©2007The American Society of Opthalmic Plastic and Reconstructive Surgery, Inc.