Brief ReportsLacrimal Gland AmyloidosisCheng, Jacob Yen Chuan M.R.C.S.(Ed.), M.MED.(Ophth.)*; Fong, Kee Siew M.Med.(Ophth.), F.R.C.S.(Ed.)*; Cheah, Elizabeth S. F.R.C.Path†; Choo, C T. F.R.C.Ophth*Author Information *Singapore National Eye Centre and †Department of Pathology, Singapore General Hospital. Accepted for publication December 7, 2005. The authors have no commercial interest in any of the material discussed in the paper. Presented as a poster at the Second SERI-ARVO Meeting on Research in Vision and Ophthalmology, Singapore, February 16–20, 2005, and at the 20th Asia-Pacific Academy of Ophthalmology Meeting, Kuala Lumpur, Malaysia, March 27–31, 2005. Address correspondence and reprint requests to Dr. Jacob Yen Chuan Cheng, Singapore National Eye Centre, 11, Third Hospital Avenue, Singapore 168751.E-mail:[email protected] Ophthalmic Plastic & Reconstructive Surgery: July 2006 - Volume 22 - Issue 4 - p 306-308 doi: 10.1097/01.iop.0000222354.44000.eb Buy Metrics AbstractIn Brief Primary localized lacrimal gland amyloidosis is an extremely rare occurrence. The typical clinical and radiologic appearances have been suggested but not clearly established. This report describes two patients with amyloid tumor of the lacrimal gland. Both patients were middle-aged women of Asian origin, one a Chinese with unilateral lacrimal gland swelling and the other, a Malay with bilateral lacrimal gland swelling. Neither patient had associated systemic disease. They were otherwise asymptomatic except for prominence over the lacrimal gland region. Neither visual impairment nor evidence of optic nerve dysfunction was noted in either patient. CT findings mimic that of an inflammatory or lymphoproliferative disorder of the lacrimal gland. The diagnosis of amyloidosis was only proved on histology. Further investigations revealed that the disease process was truly localized and not part of a systemic process. Subsequent observation proved no recurrence. A summary of the clinical and radiologic characteristics of the disorder in two patients is presented. ©2006The American Society of Opthalmic Plastic and Reconstructive Surgery, Inc.