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  • Creator:   Sarah LaCorte
  • Updated:   9/8/2021
  • Contains:  12 items
Oncology's top experts share their perspectives, opinions, and concerns about the field's most pressing issues covered in recent OT articles.

Creator: Sarah LaCorte
Duration: 20:58
Colleague Conversations offers insights into hematology/ oncology from two different perspectives: a seasoned hematologist/oncologist and an early-career clinician. In this installment, Oncology Times sat down with Christopher A. Jones, MD, MBA, HMDC, FAAHPM, and David Jonathan Casarett, MD, MA, FAAHPM, to discuss the relatively new field of palliative care. The discussion leads us through how the field has transformed oncology care, how palliative care physicians can address issues like racial disparities, and how telehealth is the wave of the future.
Creator: Sarah LaCorte
Duration: 16:52
A new study has helped to define MET amplification as a rare but potentially actionable driver for non-small cell lung cancer (NSCLC). The paper, titled “Crizotinib in Patients With MET-Amplified NSCLC,” published in the Journal of Thoracic Oncology, introduces a third means of defining NSCLC subsets that can be targeted with a specific drug. In this episode, journalist Peter Goodwin interviews study author D. Ross Camidge, MD, PhD, Director of Thoracic Oncology at the University of Colorado School of Medicine, on the recent findings.
Creator: Peter Goodwin
Duration: 39:47

What’s in the OncTimesTalk, May 2021 Edition?

New clinical findings on:
Nivolumab in gastro-esophageal cancer, CDK4/6 inhibition for breast cancer, COVID-19 vaccination limitations, sitagliptin/graft-versus-host disease, breast cancer individualization, neo-adjuvant chemotherapy for rectal cancer.
Featuring:
Ronan Kelly (Austin TX), Erica Mayer (Boston MA), Sibylle Loibl (Frankfurt, Germany), Shabir Madhi (Johannesburg South Africa) and Thierry Conroy (Nancy, France).

Interviews in this edition:

Ronan J Kelly MD MBA, Baylor University Medical Center, Dallas
Adjuvant Nivolumab “Practice Changing” in Resected Gastroesophageal Cancer
Ronan Kelly tells OncTimesTalk about a big reduction in the risk of death, and doubling of median disease-free survival, from using nivolumab as adjuvant therapy for patients with esophageal, and gastro-esophageal junction, cancers after
chemoradiotherapy plus surgery in the placebo-controlled phase-three CheckMate 577 study.
https://www.nejm.org/doi/full/10.1056/NEJMoa2032125

Erica L. Mayer MD, Dana-Farber Cancer Institute, Boston, MA
Palbociclib Added No Benefit to Breast Cancer Adjuvant Endocrine Therapy
Erica Mayer discusses the PALLAS study findings with OncTimesTalk that adding the CDK 4/6 inhibitor palbociclib to endocrine therapy failed to improve invasive disease-free survival among patients with early breast cancer despite its proven efficacy in metastatic disease.
https://www.thelancet.com/journals/lanonc/article/PIIS1470-2045(20)30642-2/fulltext

Breast Cancer: A Guide to Therapy Individualization 
Sibylle Loibl, Professor of Obstretrics and Gynaecology, University of Frankfurt, CEO and Chair, German Breast Group.
Sibylle Loibl discusses her expert panel’s findings with OncTimesTalk about optimizing the many powerful methods for managing breast cancer to individualize treatment. “Future research in breast cancer will focus not only on new drugs, but even more on the individualization of therapy for every single tumor in every single patient,” she wrote in “The Lancet”.
https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(20)32381-3/fulltext

Sherif S. Farag MD PHD, Director of the Stem Cell Transplant and Cellular Therapy, Melvin and Bren Simon Comprehensive Cancer Center, Indiana University School of Medicine, in Indianapolis
Sitagliptin Reduced Graft Versus Host Disease in Stem Cell Transplantation
A non-randomized 36-patient phase-two clinical study found a big reduction in acute graft-versus-host disease after adding the dipeptidyl peptidase-4 (DPP-4) inhibitor sitagliptin (a long established antiglycemic agent) to immunosuppression for allogeneic stem-cell transplantation.  Sherif Farag discusses the study findings with OncTimesTalk.
http://www.nejm.org/doi/full/10.1056/NEJMoa2027372

Shabir A. Madhi PhD, Professor of Vaccinology and Director of the Vaccines & Infectious Diseases Analytics Research Unit at the University of Witwatersrand in Johannesburg, Co-Director of African Leadership in Vaccinology Expertise.
SARS-CoV-2 Vaccine Was Ineffective Against B.1.351 (“South African”) Variant
A “first-generation” vaccine for COVID-19 failed to prevent mild or moderate disease caused by the B.1.351 coronavirus variant in South Africa in a randomized, double-blind, controlled trial of the ChAdOx1 nCoV-19 vaccine among relatively young adults. Shabir Madhi tells OncTimesTalk, however, that vaccination with such first-generation vaccines should still protect against severe disease and death from the new variant because T-cell responses had been preserved in the South African variant.
https://www.nejm.org/doi/full/10.1056/NEJMoa2102214

Thierry Conroy MD, Professor, Department of Medical Oncology, Institut de Cancérologie de Lorraine, 54519 Vandoeuvre-lès-Nancy, France
Neoadjuvant Chemotherapy Before Preoperative Chemoradiotherapy in Locally Advanced Rectal Cancer
A multi-center, randomized, open-label, phase-three trial has shown that outcomes for patients with rectal cancer can be improved still further by using neoadjuvant chemotherapy before the current standard of care (chemo-radiotherapy and surgery).  Professor Thierry Conroy, from the Cancer Institute in Nancy, gives OncTimesTalk the details on why they decided to try an additional treatment and the benefit it brought.
https://www.thelancet.com/journals/lanonc/article/PIIS1470-2045(21)00079-6/fulltext

Creator: Oncology Times
Duration: 13:28
Welcome to the Oncology Times Podcast. Today on the Pod - Why do relatively few leaders live good values consistently? Why are so many people, especially in academic medicine, consumed with values that are emotion-based? We will discuss these ideas and more with Dr. Brian J. Bolwell, the Chairman of the Taussig Cancer Institute and Professor of Medicine at the Cleveland Clinic Lerner School of Medicine. Today Dr. Bolwell revisits his Oncology Times column on “Values” and outlines how to grow from an individual-focused, emotion-based values system to living with more positive values.
Creator: Sarah LaCorte
Duration: 10:48
Liam Holt, PhD, speaks in analogies when describing his work focusing on compression of cancer cells and how it affects their behavior and evolution at his lab at the Institute for Systems Genetics at NYU Grossman School of Medicine. The assistant professor in the Department Of Biochemistry and Molecular Pharmacology aims to characterize how compression of cells causes genome instability specifically in pancreatic cancer.
Creator: Oncology Times
Duration: 15:05
In his recurring Oncology Times column “Straight Talk: Today's Cancer Centers,” Brian J. Bolwell, MD dispenses wisdom on how to be a better leader. In this episode, Dr. Bolwell revisits his column “Moments,” and discusses how to foster vulnerability, create psychological safety on a team, and embrace joy.
Creator: Sarah LaCorte
Duration: 12:46
Oncology Times sits down with Brian J. Bolwell, MD, the Chairman of the Taussig Cancer Institute and Professor of Medicine at the Cleveland Clinic Lerner School of Medicine. In his recurring Oncology Times column Straight Talk: Today's Cancer Centers, Dr. Bolwell dispenses wisdom on how to be a better leader. In this episode, Dr. Bolwell discusses the art of forgiveness; including how to let it go when there is conflict and breach of trust.
Creator: HemOnc Times
Duration: 9:19
Oncology Times 
Naveen Pemmaraju, MD, discusses the therapeutic landscape of ultra-rare cancers as well as the importance of ongoing research in these patient populations. Additionally, he shares his own passion for this area of study and how it has shaped his career.