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doi: 10.1097/01.COT.0000466863.72908.d7
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New clinical trials recently added to the National Cancer Institute's database

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BLADDER CANCER

Continuous Infusion of Ropivacaine Hydrochloride in Reducing Pain After Surgery in Patients With Bladder Cancer

Phase:Phase IV

Type: Health services research, Supportive care

Status: Approved-not yet active

Age: 18 and over

Sponsor: NCI, Other

Protocol IDs: 4B-14-4, NCI-2015-00279, P30CA014089, NCT02438852

Biologic Mesh in Preventing Hernia in Patients With Bladder Cancer Undergoing Radical Cystectomy With Ileal Conduit Diversion

Phase: Phase III

Type: Supportive care

Status: Approved-not yet active

Age: Not specified

Sponsor: NCI, Other

Protocol IDs: 4B-14-2, NCI-2015-00278, P30CA014089, NCT02439060

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BONE MARROW TRANSPLANTATION

Topical Phenylephrine Solution in Preventing Oral Mucosa in Bone Marrow Transplant Patients Receiving Cyclophosphamide and Total Body Radiation Therapy

Phase: Phase II, Phase I

Type: Supportive care

Status: Approved-not yet active

Age: 18 and over

Sponsor: NCI, Other

Protocol IDs: UW14068, NCI-2015-00576, P30CA014520, 2015-0062, NCT02434146

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BRAIN/CENTRAL NERVOUS SYSTEM TUMORS

Pomalidomide in Treating Younger Patients With Recurrent, Progressive or Refractory Central Nervous System Tumors

Phase: Phase I

Type: Biomarker/Laboratory analysis, Treatment

Status: Approved-not yet active

Age: 3 to 20

Sponsor: NCI

Protocol IDs: NCI-2014-02182, PBTC-043, UM1CA081457, NCT02415153

Carboxylesterase-Expressing Allogeneic Neural Stem Cells and Irinotecan Hydrochloride in Treating Patients With Recurrent High-Grade Gliomas

Phase: Phase I

Type: Biomarker/Laboratory analysis, Treatment

Status: Approved-not yet active

Age: 18 to 64

Sponsor: NCI, Other

Protocol IDs: 14108, NCI-2014-01463, NCT02192359

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BREAST CANCER

Trastuzumab Emtansine in Treating Older Patients With Human Epidermal Growth Factor Receptor 2-Positive Stage I-III Breast Cancer

Phase: Phase II

Type: Biomarker/Laboratory analysis, Treatment

Status: Approved-not yet active

Age: 65 and over

Sponsor: NCI, Other

Protocol IDs: RU011301I, NCI-2015-00468, P30CA015083, NCT02414646

Comparison of Use of Indocyanine Green and 99mTc-labeled Radiotracer for Axillary Lymphatic Mapping in Patients With Breast Cancer (“ICG”)

Phase: No phase specified

Type: Diagnostic

Status: Approved-not yet active

Age: Not specified

Sponsor: NCI, Other

Protocol IDs: CASE10114, NCT02419807

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COLORECTAL CANCER

Combination Chemotherapy and Bevacizumab With or Without PRI-724 in Treating Patients With Newly Diagnosed Metastatic Colorectal Cancer

Phase: Phase II

Type: Biomarker/Laboratory analysis, Treatment

Status: Approved-not yet active

Age: 18 and over

Sponsor: NCI, Other

Protocol IDs: 3C-13-3, NCI-2015-00436, R01CA166161, P30CA014089, NCT02413853

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HEAD AND NECK/ORAL CANCERS

Ipilimumab, Cetuximab, and Intensity-Modulated Radiation Therapy in Treating Patients With Previously Untreated Stage III-IVB Head and Neck Cancer

Phase: Phase I

Type: Biomarker/Laboratory analysis, Treatment

Status: Active

Age: 18 and over

Sponsor: NCI

Protocol IDs: NCI-2013-00807, NCI 9196, UPCI 12-084, 9196, P30CA047904, NCT01935921

Establishing Lymphedema and Fibrosis Measures in Oral Cancer Patients

Phase: No phase specified

Type: Health services research, Supportive care

Status: Approved-not yet active

Age: 21 and over

Sponsor: NCI, NIDCR, Other

Protocol IDs: VICC SUPP 1529, 1R01DE024982-01, NCT02412241

Paclitaxel and Carboplatin Before Radiation Therapy With Paclitaxel in Treating HPV-Positive Patients With Stage III-IV Oropharynx, Hypopharynx, or Larynx Cancer

Phase: Phase II

Type: Treatment

Status: Active

Age: 19 and over

Sponsor: NCI, Other

Protocol IDs: 13-000915, NCI-2013-02394, P30CA016042, NCT02048020

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LEUKEMIA/LYMPHOMA

Bendamustine, Obinutuzumab, and Dexamethasone in Older Patients With Diffuse Large B-cell Lymphoma

Phase: Phase II

Type: Biomarker/Laboratory analysis, Treatment

Status: Approved-not yet active

Age: 70 and over

Sponsor: NCI, Other

Protocol IDs: IRB14-1120, NCI-2015-00355, P30CA014599, NCT02420210

CD8+ Memory T-Cells as Consolidative Therapy After Donor Non-myeloablative Hematopoietic Cell Transplant in Treating Patients With Leukemia or Lymphoma

Phase: Phase II

Type: Biomarker/Laboratory analysis, Treatment

Status: Approved-not yet active

Age: 18 to 75

Sponsor: NCI, Other

Protocol IDs: IRB-33058, NCI-2015-00567, 351, BMT288, P30CA124435, NCT02424968

CDK4/6 Inhibitor LEE011 and Gemcitabine Hydrochloride in Treating Patients With Advanced Solid Tumors or Lymphoma

Phase: Phase I

Type: Biomarker/Laboratory analysis, Treatment

Status: Approved-not yet active

Age: 18 and over

Sponsor: NCI, Other

Protocol IDs: I 262914, NCI-2015-00280, P30CA016056, NCT02414724

Central Memory Enriched T Cells Following Stem Cell Transplant in Treating Patients With Recurrent B-Cell Non-Hodgkin Lymphoma

Phase: Phase I

Type: Biomarker/Laboratory analysis, Treatment

Status: Active

Age: 18 and over

Sponsor: NCI, Other

Protocol IDs: 13277, NCI-2014-00133, P50CA107399, NCT02051257

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LUNG CANCER

S1403, Afatinib Dimaleate With or Without Cetuximab in Treating Patients With Newly Diagnosed Stage IV or Recurrent, EGFR Mutation Positive Non-small Cell Lung Cancer

Phase: Phase III, Phase II

Type: Biomarker/Laboratory analysis, Treatment

Status: Active

Age: Not specified

Sponsor: NCI, Other

Protocol IDs: S1403, NCI-2014-02405, U10CA180888, NCT02438722

TORC1/2 Inhibitor MLN0128 in Treating Patients With Stage IV or Recurrent Lung Cancer

Phase: Phase II

Type: Biomarker/Laboratory analysis, Treatment

Status: Approved-not yet active

Age: 18 and over

Sponsor: NCI

Protocol IDs: NCI-2015-00545, 2015-00500, 9780, P30CA008748, NCT02417701

Pharmacological Ascorbate for Lung Cancer

Phase: Phase II

Type: Biomarker/Laboratory analysis, Treatment

Status: Active

Age: 18 and over

Sponsor: NCI, Other

Protocol IDs: 201412760, 3P30CA086862, NCT02420314

Pemetrexed Disodium in Treating Patients With Stage IV Non-small Cell Lung Cancer and ECOG Performance Status 3

Phase: Phase II

Type: Biomarker/Laboratory analysis, Treatment

Status: Approved-not yet active

Age: 18 and over

Sponsor: NCI, Other

Protocol IDs: CCCWFU # 62115, NCI-2015-00596, P30CA012197, NCT02426658

CareSTEPS: A Supportive Care Program for the Caregivers of Advanced Lung Cancer Patients

Phase: No phase specified

Type: Supportive care

Status: Active

Age: 18 and over

Sponsor: NCI, Other

Protocol IDs: GCO 13-1535, R01CA187143, NCT02414672

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MYELOMA

Allogeneic Hematopoietic Stem Cell Transplantation With Ixazomib for High Risk Multiple Myeloma (BMT CTN 1302)

Phase: Phase II

Type: Treatment

Status: Approved-not yet active

Age: 18 to 65

Sponsor: NCI, NHLBI

Protocol IDs: BMTCTN1302, U01HL069294-05, NCT02440464

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OVARIAN CANCER

Intensive Locoregional Chemoimmunotherapy for Recurrent Ovarian Cancer Plus Intranodal DC Vaccines

Phase: Phase II, Phase I

Type: Treatment

Status: Approved-not yet active

Age: 18 and over

Sponsor: NCI

Protocol IDs: 11-128, 5P01CA132714, NCT02432378

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PAIN MANAGEMENT

Epidural Anesthesia Within an Enhanced Recovery Pathway in Reducing Pain in Patients Undergoing Gynecologic Surgery

Phase: Phase III

Type: Biomarker/Laboratory analysis, Supportive care

Status: Active

Age: 18 and over

Sponsor: NCI, Other

Protocol IDs: UW14030, NCI-2015-00395, P30CA014520, NCT02423876

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PANCREATIC CANCER

Paclitaxel Albumin-Stabilized Nanoparticle Formulation and Gemcitabine Hydrochloride Followed by Radiation Therapy Before Surgery in Treating Patients With Pancreatic Cancer That Can Be Removed by Surgery

Phase: Phase II

Type: Biomarker/Laboratory analysis, Treatment

Status: Approved-not yet active

Age: 18 and over

Sponsor: NCI, Other

Protocol IDs: 11256, NCI-2015-00498, SOL-14124-L, P30CA069533, NCT02427841

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PROSTATE CANCER

Metformin Hydrochloride and Aspirin in Treating Patients With Hormone-Dependent Prostate Cancer That Has Progressed After Surgery or Radiation Therapy

Phase: Phase II

Type: Biomarker/Laboratory analysis, Treatment

Status: Approved-not yet active

Age: 18 and over

Sponsor: NCI, Other

Protocol IDs: 081501, NCI-2015-00397, P30CA072720, NCT02420652

Using Multiparametric MRI to Evaluate Intraprostatic Tumor Responses and Androgen Resistance Patterns in Newly Diagnosed Prostate Cancer

Phase: Phase II

Type: Treatment

Status: Active

Age: 18 and over

Sponsor: NCI

Protocol IDs: 150124, 15-C-0124, NCT02430480

Hydroxychloroquine in Blocking Autophagy in Patients With Prostate Cancer Undergoing Surgery or Active Surveillance

Phase: No phase specified

Type: Biomarker/Laboratory analysis, Treatment

Status: Active

Age: 18 and over

Sponsor: NCI, Other

Protocol IDs: 121102, NCI-2014-02216, 0220110278, P30CA072720, NCT02421575

Informed Decision Making Intervention in Screening for Prostate Cancer of Predominantly African American Participants in a Community Outreach Program

Phase: No phase specified

Type: Educational/Counseling/Training, Natural history/Epidemiology, Screening

Status: Approved-not yet active

Age: 18 and over

Sponsor: NCI, Other

Protocol IDs: CASE3815, NCI-2015-00478, P30CA043703, NCT02419846

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SOLID TUMORS, UNSPECIFIED

In Situ, Autologous Therapeutic Vaccination Against Solid Cancers With Intratumoral Hiltonol®

Phase: Phase II

Type: Treatment

Status: Active

Age: 14 and over

Sponsor: NCI, Pharmaceutical / Industry

Protocol IDs: ONC2014-001, 1R44CA183075-01A1, NCT02423863

CDK4/6 Inhibitor LEE011 and Gemcitabine Hydrochloride in Treating Patients With Advanced Solid Tumors or Lymphoma

Phase: Phase I

Type: Biomarker/Laboratory analysis, Treatment

Status: Approved-not yet active

Age: 18 and over

Sponsor: NCI, Other

Protocol IDs: I 262914, NCI-2015-00280, P30CA016056, NCT02414724

Vaccine Therapy and Pembrolizumab in Treating Patients With Solid Tumors That Have Failed Prior Therapy

Phase: Phase I

Type: Biomarker/Laboratory analysis, Treatment

Status: Approved-not yet active

Age: 18 and over

Sponsor: NCI, Other

Protocol IDs: 15002, NCI-2015-00653, NCT02432963

4 -Thio-2 -Deoxycytidine (TdCyd) in People With Advanced Solid Tumors

Phase: Phase I

Type: Biomarker/Laboratory analysis, Treatment

Status: Active

Age: 18 and over

Sponsor: NCI

Protocol IDs: 150116, 15-C-0116, NCT02423057

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URINARY TRACT CANCER

Chemotherapy Before Surgery in Treating Patients With High Grade Upper Urinary Tract Cancer

Phase: Phase II

Type: Biomarker/Laboratory analysis, Treatment

Status: Approved-not yet active

Age: 18 and over

Sponsor: NCI, Other

Protocol IDs: EA8141, NCI-2014-02267, U10CA180820, NCT02412670

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MISCELLANEOUS/OTHER

AZD9150, a STAT3 Antisense Oligonucleotide, in People With Malignant Ascites

Phase: Phase II

Type: Biomarker/Laboratory analysis, Treatment

Status: Active

Age: 18 and over

Sponsor: NCI

Protocol IDs: 150112, 15-C-0112, NCT02417753

Ibrutinib in Treating Patients With Advanced Systemic Mastocytosis

Phase: Phase II

Type: Biomarker/Laboratory analysis, Treatment

Status: Active

Age: 18 and over

Sponsor: NCI

Protocol IDs: HEMMPD0021, NCI-2014-02341, P30CA124435, NCT02415608

Methylprednisolone Sodium Succinate in Treating Patients With Acute Graft-versus-Host Disease of the Gastrointestinal Tract

Phase: Phase II

Type: Treatment

Status: Approved-not yet active

Age: 18 and over

Sponsor: NCI, Other

Protocol IDs: CCCWFU 98115, NCI-2015-00548, P30CA012197, NCT02425813

Nivolumab in Treating Patients With Advanced Uterine Leiomyosarcoma

Phase: Phase II

Type: Biomarker/Laboratory analysis, Treatment

Status: Active

Age: 18 and over

Sponsor: NCI

Protocol IDs: NCI-2014-02403, 9672, P30CA006516, UM1CA186709, NCT02428192

Surgery in Treating Patients With Early Stage Anal Canal or Perianal Cancer and HIV Infection

Phase: Phase II

Type: Biomarker/Laboratory analysis, Treatment

Status: Active

Age: Not specified

Sponsor: NCI, Other

Protocol IDs: AMC-092, NCI-2014-02056, U01CA121947, NCT02437851

Differences in Eating Frequency Between Vegan and Omnivorous Diets

Phase: Phase I

Type: Natural history/Epidemiology

Status: Active

Age: 18 and over

Sponsor: NCI, Other

Protocol IDs: Pro00043598, 1R21CA187929-01A1, NCT02417480

Neihulizumab in Treating Patients With Steroid Refractory Acute Graft-versus-Host Disease After Donor Stem Cell Transplant

Phase: Phase I

Type: Biomarker/Laboratory analysis, Supportive care

Status: Active

Age: 18 and over

Sponsor: NCI

Protocol IDs: BMT285, NCI-2015-00631, IRB-32842, 348, P30CA124435, NCT02436460

Pembrolizumab and Docetaxel or Gemcitabine Hydrochloride in Treating Patients Urothelial Cancer

Phase: Phase I

Type: Biomarker/Laboratory analysis, Treatment

Status: Approved-not yet active

Age: 18 and over

Sponsor: NCI, Other

Protocol IDs: UCDCC#252, NCI-2015-00426, P30CA093373, 51521, NCT02437370

Smoking Cessation Self-Help for Dual Users of Tobacco Cigarettes and E-Cigarettes

Phase: No phase specified

Type: Behavioral study, Health services research

Status: Active

Age: 18 and over

Sponsor: NCI, Other

Protocol IDs: MCC-18127, R01DA037961-01A1, NCT02416011

Improving Sun-Protective Behaviors and Skin Self-Examinations Among African Americans

Phase: No phase specified

Type: Educational/Counseling/Training, Prevention

Status: Active

Age: 18 and over

Sponsor: NCI, Other

Protocol IDs: CASE1615, NCI-2015-00481, P30CA043703, NCT02417948

Health-Related Symptom Questionnaires in Measuring Quality of Life in HIV-Infected Participants Treated or Monitored for Anal Lesions

Phase: No phase specified

Type: Natural history/Epidemiology

Status: Active

Age: 35 and over

Sponsor: NCI, Other

Protocol IDs: AMC-A02, NCI-2015-00160, AMC Protocol #A02, U01CA121947, NCT02418494

Use of High-Resolution Microendoscopy (HRME) in Patients With Cervical Dysplasia

Phase: No phase specified

Type: Diagnostic

Status: Approved-not yet active

Age: 21 and over

Sponsor: NCI, Other

Protocol IDs: 2014-0368, HHSN261200800001E, 1R01CA186132, NCT02420665

Capsule Marking Using an OFDI Capsule

Phase: No phase specified

Type: Diagnostic

Status: Active

Age: 18 and over

Sponsor: NCI, Other

Protocol IDs: 2013-P001254, 5R01CA103769-08, NCT02422433

Human Prostate Tissue Model to Maintain and Study Prostate Cancer Stem Cells

Phase: No phase specified

Type: Biomarker/Laboratory analysis

Status: Approved-not yet active

Age: Not specified

Sponsor: NCI, Other

Protocol IDs: CCCWFU 85A15, NCI-2015-00377, P30CA012197, NCT02425800

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