CAR Targeting CD19 T-Cells: Durable Remissions in Children with Relapsed, Refractory ALL
Stephan A. Grupp, MD, PhD, Professor of Pediatrics and Director of Translational Research at the Center for Childhood Cancer Research at Children's Hospital of Philadelphia, discussed his team's study showing that for children with relapsed and refractory acute lymphoblastic leukemia, engineered T-cells that target CD19 appeared to induce durable responses without the need for subsequent therapy such as stem cell transplantation (Abstract 380, OT 1/25/15 issue).
Vosaroxin Added to Cytarabine Extended Survival in First-Relapsed or Refractory AML
Farhad Ravandi, MD, Professor of Medicine in the Department of Leukemia at the University of Texas MD Anderson Cancer Center, discussed the results of the Phase III VALOR study showing that the quinolone derivative vosaroxin added to cytarabine should be considered a new standard for salvage therapy in patients with relapsed or refractory acute myeloid leukemia. The multinational study is one of the largest ever conducted in this group of patients, including some 700 patients randomized to receive either the new agent or a placebo combined with cytarabine therapy (Abstract LBA-6; OT 1/25/15 issue). Also commenting is David P. Steensma, MD, Associate Professor of Medicine, Hematologic Oncology, at Harvard Medical School, who moderated a news conference at the meeting that featured the study.
Myeloma: Triple Therapy Extends Survival in Relapsed Disease
A. Keith Stewart, MD, Dean for Research and Professor of Cancer Research at the Mayo Clinic in Arizona, discusses the much-talked-about ASPIRE study showing that the three-drug combination of lenalidomide, dexamethasone, and carfilzomib, increases progression-free survival to an “unprecedented” level and improves complete remission rates in patients with relapsed multiple myeloma (Abstract 79, OT 1/10/15 issue). Also commenting is Brad H. Kahl, MD, Clinical Research Director for Hematologic Malignancies at the University of Wisconsin Carbone Cancer Center.
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