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A Perioperative Course of Gabapentin Does Not Produce a Clinically Meaningful Improvement in Analgesia After Cesarean Delivery

Monks, D.T.; Hoppe, D.W.; Downey, K.; Shah, V.; Bernstein, P.; Carvalho, J.C.

doi: 10.1097/01.aoa.0000482646.93258.e2
General Anesthesia: Postoperative Analgesia

(Anesthesiology. 2015;123:320–326)

Gabapentin is an analgesic that has proven itself to be beneficial perioperatively for several surgeries, some of which, such as abdominal hysterectomy, are similar to cesarean delivery. There is also extensive information on this drug from its use as an anticonvulsant, in which it has been shown to be safe for use during pregnancy and breastfeeding. But while there have been studies evaluating its efficacy for pain management following cesarean delivery, studies evaluating use of a single preoperative dose for pain management following cesarean delivery have not produced definitive results. The authors of this trial sought to test the analgesic effect of gabapentin when given perioperatively for cesarean delivery.

Departments of Anesthesia, Paediatrics and Obstetrics and Gynecology, Mount Sinai Hospital, University of Toronto, Toronto, ON, Canada

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