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The Mediating Effects of Gestational Diabetes on Fetal Growth and Adiposity in Women Who are Overweight and Obese

Secondary Analysis of the LIMIT Randomized Trial

Poprzeczny, A.J.; Louise, J.; Deussen, A.R.; Dodd, J.M.

doi: 10.1097/01.aoa.0000575252.84187.fc
Mother, Fetus, Neonate

(BJOG. 2018;125:1558–1566.)

Overweight and obesity represent a significant impact on the world’s public health, and are associated with increased risks of adverse maternal and infant outcomes during pregnancy and delivery. As maternal body mass index (BMI) increases, gestational diabetes mellitus (GDM) also increases in prevalence. GDM is associated with adverse perinatal outcomes similar to those seen in obese pregnant women, including the need for induction of labor and cesarean section, and having an infant born large for gestational age or birthweight over 4 kg. The aim of this secondary analysis from the LIMIT randomized trial was to describe the mediating effect of GDM in obese pregnant women on fetal growth and adiposity.

Discipline of Obstetrics and Gynaecology, The Robinson Research Institute, The University of Adelaide, Adelaide, SA, Australia; Department of Obstetrics and Gynaecology, Lyell McEwin Hospital, Elizabeth, SA, Australia

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