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Hypnotic Agents for Induction of General Anesthesia in Caesarean Section Patients

A Systematic Review and Meta-Analysis of Randomized Controlled Trials

Houthoff Khemlani, K.; Weibel, S.; Kranke, P.; Schreiber, J.U.

doi: 10.1097/01.aoa.0000557696.00871.81
Anesthesia and Analgesia: General Anesthesia
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(J Clin Anesth. 2018;48:73–80)

Thiopentone is a well-known general anesthesia induction agent for cesarean section (CS). Alternative agents include benzodiazepines, ketamine, and propofol. However, all these agents are lipid soluble and have rapid maternal-fetal equilibration. There is no reliable evidence available to support the use of any one of these specific drugs as a dedicated hypnotic agent in the setting of general anesthesia in CS patients. Therefore, to identify an “evidence-supported” practice, the authors of the present study conducted a meta-analysis as per PRISMA guidelines to compare the efficacy and safety profiles of benzodiazepines, ketamine, and propofol to that of thiopentone.

Department of Anesthesia and Pain Management, Maastricht University Medical Center, Maastricht, The Netherlands

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