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Maternal Cardiac Output Response to Colloid Preload and Vasopressor Therapy During Spinal Anesthesia for Cesarean Section in Patients With Severe Preeclampsia

A Randomized, Controlled Trial

Dyer, R.A.; Daniels, A.; Vorster, A.; Emmanuel, A.; Arcache, M.J.; Schulein, S.; Reed, A.R.; Lombard, C.J.; James, M.F.; van Dyk, D.

doi: 10.1097/01.aoa.0000547272.20090.eb
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(Anaesthesia. 2018;73:23–31)

Minimally invasive cardiac output monitors have been used in parturients to assess the hemodynamic effects of spinal anesthesia and the commonly used vasopressors phenylephrine and ephedrine. However, studies utilizing these devices have been performed mostly in healthy parturients, with data lacking for those with severe preeclampsia. This randomized study’s objective was to compare the cardiac output response to phenylephrine or ephedrine administered for spinal hypotension during cesarean delivery in women with severe early-onset preeclampsia as well as to measure the stroke volume response to administration of a colloid preload.

Department of Anaesthesia and Perioperative Medicine, University of Cape Town, Cape Town, South Africa

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