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Risk of Adverse Pregnancy Outcomes at Advanced Maternal Age

Frederiksen, L.E.; Ernst, A.; Brix, N.; Braskhøj Lauridsen, L.L.; Roos, L.; Ramlau-Hansen, C.H.; Ekelund, C.K.

doi: 10.1097/01.aoa.0000542378.64975.41
Mother, Fetus, Neonate
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(Obstet Gynecol 2018;131:457–463)

Previous studies examining associations between advanced maternal age and adverse pregnancy outcomes have conflicting findings, are inadequately powered, or are prone to bias. The authors of the present study thereby examined the possible associations between advanced maternal age (above 35 y of age) and adverse pregnancy outcomes in a large population-based cohort of pregnant women in Denmark, followed from first trimester to delivery or termination of pregnancy. The authors also predicted risk estimates of a composite adverse pregnancy outcome, to identify whether certain groups of parturients are at risk for select adverse pregnancy outcomes.

Department of Public Health and the Department of Public Health, Section for Epidemiology, Aarhus University, Aarhus; Department of Clinical Genetics, Juliane Marie Centre, and the Department of Obstetrics, Center of Fetal Medicine, Rigshospitalet, Copenhagen, Denmark

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