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Effects of Therapeutic Hypothermia Initiated After 6 Hours of Age on Death or Disability Among Newborns With Hypoxic-ischemic Encephalopathy

Laptook, A.R.; Shankaran, S.; Tyson, J.E.; Munoz, B.; Bell, E.F.; Goldberg, R.N.; Parikh, N.A.; Ambalavanan, N.; Pedroza, C.; Pappas, A.; Das, A.; Chaudhary, A.S.; Ehrenkranz, R.A.; Hensman, A.M.; Van Meurs, K.P.; Chalak, L.F.; Hamrick, S.E.G.; Sokol, G.M.; Walsh, M.C.; Poindexter, B.B.; Faix, R.G.; Watterberg, K.L.; Frantz, I.D. III; Guillet, R.; Devaskar, U.; Truog, W.E.; Chock, V.Y.; Wyckoff, M.H.; McGowan, E.C.; Carlton, D.P.; Harmon, H.M.; Brumbaugh, J.E.; Cotten, C.M.; Sánchez, P.J.; Hibbs, A.M.; Higgins, R.D. for the Eunice Kennedy Shriver National Institute of Child Health and Human Development Neonatal Research Network

doi: 10.1097/01.aoa.0000542372.34481.78
Mother, Fetus, Neonate

(JAMA 2017;318(16):1550–1560)

Previous trials have shown therapeutic hypothermia reduces death or disability when infants with hypoxic-ischemic encephalopathy are treated within 6 hours after birth. Getting infants treated in this window can be difficult when transportation is necessary or when encephalopathy is not recognized within 6 hours. This study aimed to determine whether hypothermia treatment can reduce the risk of death or disability due to hypoxic-ischemic encephalopathy at 18 months when treatment is initiated between 6 and 24 hours after birth.

Department of Pediatrics, Women & Infants Hospital, Brown University, Providence, RI

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