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Recovery From Ropivacaine-induced or Levobupivacaine-induced Cardiac Arrest in Rats: Comparison of Lipid Emulsion Effects

Yoshimoto, M.; Horiguchi, T.; Kimura, T.; Nishikawa, T.

Obstetric Anesthesia Digest: June 2018 - Volume 38 - Issue 2 - p 85
doi: 10.1097/01.aoa.0000532278.13344.e5
Mechanisms, Equipment, Hazards

(Anesth Analg. 2017;125(5):1496–1502)

Levobupivacaine and ropivacaine are 2 pure left-handed enantiomers that have less potential for central nervous system and cardiovascular system toxicity than bupivacaine. However, the potential for systemic toxicity still exists; comparative studies have found that a larger dose of ropivacaine than levobupivacaine is required to produce cardiac collapse in animal models. Intravenous lipid emulsion is a potential rescue therapy. As comparisons of lipid emulsion therapy between levobupivacaine-induced and ropivacaine-induced cardiac arrest have not been reported, the authors of the present study evaluated the difference in efficacy of this rescue therapy to treat cardiac arrest induced by these local anesthetics in awake rats.

Department of Anesthesia and Intensive Care Medicine, Akita University Graduate School of Medicine, Akita, Japan

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