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Novel Oxytocin Receptor Variants in Laboring Women Requiring High Doses of Oxytocin

Reinl, E.L.; Goodwin, Z.A.; Raghuraman, N.; Lee, G.Y.; Jo, E.Y.; Gezahegn, B.M.; Pillai, M.K.; Cahill, A.G.; de Guzman Strong, C.; England, S.K.

Obstetric Anesthesia Digest: June 2018 - Volume 38 - Issue 2 - p 93–94
doi: 10.1097/01.aoa.0000532289.07506.18
Mechanisms, Equipment, Hazards

(Am J Obstet Gynecol. 2017;217(2):214.e1–214.e8)

In the United States, oxytocin is administered to nearly half of women who give birth to either augment or induce labor. However, the required dosage of oxytocin varies widely among women, with a therapeutic window between 1 mU/min and >40 mU/min. Variations in the oxytocin receptor gene may explain some women’s requirements for high or low doses of oxytocin. This study aimed to identify variants in the oxytocin receptor gene in women in labor who had high or low dosage requirements.

Department of Obstetrics and Gynecology, Center for Reproductive Health Sciences, School of Medicine, Washington University in St. Louis, St. Louis, MO

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