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Noninfectious Fever in the Near-Term Pregnant Rat Induces Fetal Brain Inflammation: A Model for the Consequences of Epidural-associated Maternal Fever

Segal, S.; Pancaro, C.; Bonney, I.; Marchand, J.E.

Obstetric Anesthesia Digest: June 2018 - Volume 38 - Issue 2 - p 59–60
doi: 10.1097/01.aoa.0000532250.93150.8c
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(Anesth Analg. 2017;125(6):2134–2140)

Intrapartum fever of noninfectious etiology during deliveries in women with labor epidural analgesia may adversely affect the developing fetal brain. A proinflammatory cytokine, interleukin (IL)-6, found to be present at increased levels in epidural-associated maternal fever, has been linked to neonatal brain injury. As there is no comprehensive animal model of labor epidural analgesia, the authors of the present study developed a model of noninfectious inflammatory fever in the near-term pregnant rat using IL-6 levels comparable to those found in human patients with labor epidural analgesia-associated fever. They hypothesized that brief administration of IL-6 would induce a core temperature increase in the dams and induce neuroinflammation in the fetus.

Department of Anesthesiology, Wake Forest School of Medicine, Winston-Salem, NC

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