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Genetic Associations With Gestational Duration and Spontaneous Preterm Birth

Zhang, G.; Feenstra, B.; Bacelis, J.; Liu, X.; Muglia, L.M.; Juodakis, J.; Miller, D.E.; Litterman, N.; Jiang, P.P.; Russell, L.; Hinds, D.A.; Hu, Y.; Weirauch, M.T.; Chen, X.; Chavan, A.R.; Wagner, G.P.; Pavličev, M.; Nnamani, M.C.; Maziarz, J.; Karjalainen, M.K.; Rämet, M.; Sengpiel, V.; Geller, F.; Boyd, H.A.; Palotie, A.; Momany, A.; Bedell, B.; Ryckman, K.K.; Huusko, J.M.; Forney, C.R.; Kottyan, L.C.; Hallman, M.; Teramo, K.; Nohr, E.A.; Davey Smith, G.; Melbye, M.; Jacobsson, B.; Muglia, L.J.

Obstetric Anesthesia Digest: June 2018 - Volume 38 - Issue 2 - p 72
doi: 10.1097/
Epidemiologic Reports, Surveys

(N Engl J Med. 2017;377(12):1156–1167)

Preterm birth is the leading cause of death in neonates and children above 5 years of age. Its definition, birth before 37 completed weeks of gestation, is a dichotomous trait based on a somewhat arbitrary cutoff of weeks’ gestation, rather than time of birth or a level of fetal maturity. Therefore, in the present study, the authors tested genetic associations with gestational duration (a quantitative trait) and preterm birth (a dichotomous trait), in order to identify robust associations with genetic variants consistent with a role in the timing of birth.

Division of Human Genetics, Cincinnati Children’s Hospital Medical Center, and the Center for Prevention of Preterm Birth, Perinatal Institute, Cincinnati Children’s Hospital Medical Center and March of Dimes Prematurity Research Center Ohio Collaborative, Cincinnati, OH

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