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The Role of Aspirin Dose on the Prevention of Preeclampsia and Fetal Growth Restriction: Systematic Review and Meta-Analysis

Roberge, S.; Nicolaides, K.; Demers, S.; Hyett, J.; Chaillet, N.; Bujold, E.

Obstetric Anesthesia Digest: March 2017 - Volume 37 - Issue 1 - p 9
doi: 10.1097/01.aoa.0000511998.98893.df
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(Am J Obstet Gynecol. 2016 pii: S0002-9378(16)30783–30789)

Preeclampsia (PE) and fetal growth restriction (FGR) are important causes of perinatal morbidity and mortality. Several studies have suggested that the prophylactic use of low-dose aspirin may help to reduce risk in pregnant women. However, the optimal dosage remains unclear. Therefore, these authors performed a systematic review and meta-analyses of randomized controlled trials and evaluated the dose-response effect of aspirin on the prevention of PE and FGR.

Department of Obstetrics and Gynecology, Faculty of Medicine, Université Laval, Quebec City, QC, Canada

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