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The Effects of Vasopressin and Oxytocin on the Fetoplacental Distal Stem Arteriolar Vascular Resistance of the Dual-Perfused, Single, Isolated, Human Placental Cotyledon

Downing, John W. MD; Baysinger, Curtis L. MD; Johnson, Raymond F. BS; Paschall, Ray L. MD; Shotwell, Matthew S. PhD

doi: 10.1097/01.aoa.0000512014.41956.44
Mechanisms, Equipment, Hazards

(Anesth Analg. 2016;123:698–702)

Maternal hypotension during cesarean delivery can be treated with vasoactive agents like ephedrine, phenylephrine, or vasopressin. However, these agents may intensify hypoxemic fetoplacental vasoconstrictor responses and inhibit placental oxygen flow. In the present study, the authors hypothesized that vasopressin, a systemic vasoconstrictor, and oxytocin, an uterotonic agent with systemic vasodilator properties, would not influence distal stem villous arteriolar resistance.

Departments of Anesthesiology and Biostatistics, Vanderbilt University School of Medicine, Nashville, TN

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