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Repeated Isoflurane Exposure and Neuroapoptosis in the Midgestation Fetal Sheep Brain

Olutoye, Olutoyin A. MD, MSc; Sheikh, Fariha MD; Zamora, Irving J. MD; Yu, Ling BS; Akinkuotu, Adesola C. MD; Adesina, Adekunle M. MD, PhD; Olutoye, Oluyinka O. MD, PhD

Obstetric Anesthesia Digest: March 2017 - Volume 37 - Issue 1 - p 21
doi: 10.1097/01.aoa.0000512013.34333.1b
Mechanisms, Equipment, Hazards
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(Am J Obstet Gynecol. 2016;214:542.e1–542.e8)

Despite current concerns about the detrimental effects of anesthesia on the developing brain, advances in surgery and technology allow for a variety of fetal interventions. Evidence has shown that the inhalational anesthetic agent, isoflurane, other gamma amino butyric acid agonists and N-methyl D aspartate antagonists induce neuroapoptosis. To study maternal-fetal physiological interactions and to investigate different surgical interventions on the fetus, the ovine model has been used extensively. The objective of this study was to determine the effects of different doses and duration of isoflurane on neuroapoptosis in midgestation fetal sheep.

Department of Anesthesiology Baylor College of Medicine and Texas Children’s Fetal Center Texas Children’s Hospital, Houston, TX

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