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Randomized Study of Postcesarean Analgesia With Intrathecal Morphine Alone or Combined With Clonidine

Carvalho, F.A.; Tenório, S.B.; Shiohara, F.T.; Maia, L.R.; Mota, A.

doi: 10.1097/01.aoa.0000512038.50473.d6
Anesthesia and Analgesia: Postoperative Analgesia

(J Clin Anesth. 2016;33:395–402)

Intrathecal morphine provides long-lasting pain relief after cesarean deliveries but can be difficult to dose properly (range is 25 to 500 μg). It is possible that the concomitant use of clonidine, an alpha-2-adrenoceptor agonist, with morphine may help to improve the quality of analgesia and reduce opioid consumption and side effects. Therefore, the authors of the present study compared the efficacy of 50 μg intrathecal morphine combined with 75 μg clonidine to the efficacy of 50 μg or 100 μg intrathecal morphine alone for postcesarean analgesia.

Department of Anesthesiology and Pain Treatment, Hospital Santa Cruz, Paraná, Brazil

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