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Pharmacokinetics and Pharmacodynamics of Drugs Commonly Used in Pregnancy and Parturition

Ansari, Jessica MD; Carvalho, Breandan MBBCh, FRCA, MDCH; Shafer, Steven L. MD; Flood, Pamela MD, MA

doi: 10.1097/01.aoa.0000504701.05570.8d
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Commentary

(Anesth Analg 2016;122:786–804)

There is a lack of pharmacokinetic and pharmacodynamic studies in parturients. In addition, while current regulations require such studies to be conducted in women of childbearing potential, very few medications have been studied in the setting of pregnancy, with most drugs being used off-label. As such, there are inadequate data for physicians and patients to make informed decisions regarding drug use during pregnancy and lactation. In this review, the authors discussed known alterations in drug pharmacokinetics and pharmacodynamics that occur during pregnancy as well as the impact of acute changes in physiology during childbirth.

Department of Anesthesiology, Perioperative and Pain Medicine, Stanford University, Stanford, California

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