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Effects of Intrathecal κ-Opioid Receptor Agonist on Morphine-induced Itch and Antinociception in Mice

Sakakihara, M.; Imamachi, N.; Saito, Y.

Obstetric Anesthesia Digest: December 2016 - Volume 36 - Issue 4 - p 222
doi: 10.1097/01.aoa.0000504754.26367.d9
Anesthesia and Analgesia: Postoperative Analgesia
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(Reg Anesth Pain Med. 2016;41:69–74)

The μ-opioid receptor agonist-induced itch is a common adverse effect associated with opioid pain treatment administered through systemic, spinal, and epidural routes. Studies have suggested that systemically administered κ-opioid receptor (KOR) agonists alleviate intrathecal morphine-induced itch; moreover, systemic KOR agonists in combination with intrathecal morphine display additive antinociceptive effects against a thermal stimulus in primates. However, adverse effects, such as insomnia induced by systemically administered KOR agonists, may limit the usefulness of their antipruritic effects in patients. The aim of this study was to investigate the effects of intrathecal TRK-820 a KOR agonist, on intrathecal morphine-induced itch, antinociception, and sedation.

Department of Anesthesiology, Shimane University Faculty of Medicine, Shimane, Japan

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