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Predictive Value of the sFlt-1: PlGF Ratio in Women With Suspected Preeclampsia

Zeisler, H. MD; Llurba, E. MD, PhD; Chantraine, F. MD, PhD; Vatish, M. MB, ChB, DPhil; Cathrine Staff, A. MD, PhD; Sennström, M. MD, PhD; Olovsson, M. MD, PhD; Brennecke, S.P. MB, BS, DPhil; Stepan, H. MD; Allegranza, D. BA; Dilba, P. MSc; Schoedl, M. PhD; Hund, M. PhD; Verlohren, S. MD, PhD

doi: 10.1097/01.aoa.0000489468.07157.ab
Mechanisms, Equipment, Hazards

(N Engl J Med. 2016;374:13–22)

Preeclampsia is a serious multisystem disorder affecting up to 5% of pregnancies worldwide. A reliable predictor of preeclampsia would be helpful in allowing health care providers to identify women at risk for developing the disorder. Serum levels of circulating maternal soluble fms-like tyrosine kinase 1 (sFlt-1) are known to be elevated in preeclampsia, while levels of placental growth factor (PlGF) are decreased. A high ratio of sFlt-1 to PlGF indicates an increased risk for preeclampsia and could potentially be a more reliable predictor than either of those factors alone. The authors of this study sought to evaluate the ratio as a predictive tool among women with suspected preeclampsia.

Department of Obstetrics and Gynecology, Medical University Vienna, Vienna, Austria

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