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Effects of Preoperative Serotonin-Receptor-Antagonist Administration in Spinal Anesthesia-induced Hypotension: A Randomized, Double-blind Comparison Study of Ramosetron and Ondansetron

Shin, H.J.; Choi, E.S.; Lee, G.W.; Do, S.H.

doi: 10.1097/01.aoa.0000489464.84285.72
Mechanisms, Equipment, Hazards
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(Reg Anesth Pain Med. 2015;40(5):583–588)

Spinal anesthesia is associated with adverse effects such as arterial hypotension and bradycardia. The goal of this study was to evaluate the efficacy of 2 serotonin receptor antagonists in preventing these effects. Ramosetron is a receptor antagonist that is stronger and longer-lasting than others of its kind and has been observed to decrease hypotension resulting from spinal anesthesia. Ondansetron is another receptor antagonist that has been reported to diminish spinal-anesthesia–related hypotension in both obstetric and nonobstetric patients.

Department of Anesthesiology and Pain Medicine, Seoul National University Bundang Hospital, Seongnam, Gyeonggi, South Korea

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