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Ondansetron Does Not Attenuate Hemodynamic Changes in Patients Undergoing Elective Cesarean Delivery Using Subarachnoid Anesthesia

Terkawi, A.S.; Tiouririne, M.; Mehta, S.H.; Hackworth, J.M.; Tsang, S.; Durieux, M.E.

Obstetric Anesthesia Digest: June 2016 - Volume 36 - Issue 2 - p 81–82
doi: 10.1097/01.aoa.0000482615.33162.f6
Mechanisms, Equipment, Hazards
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Commentary

(Reg Anesth Pain Med. 2015;40:344–348)

The most common side effect of subarachnoid (SA) anesthesia for cesarean delivery (CD) is hypotension, and the use of serotonin receptor-blocking drugs has been suggested as a possible treatment for this. One receptor antagonist that has been proposed for this use in both obstetric and nonobstetric settings is ondansetron. However, current studies regarding the use of ondansetron are either underpowered or have reported conflicting results. The purpose of this study was to determine how useful ondansetron actually is in the prevention of hypotension, particularly when it is administered intravenously and prophylactically to women undergoing elective CD.

Department of Anesthesiology, University of Virginia, Charlottesville, VA

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