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A Systematic Review of the Effects of Adding Neostigmine to Local Anesthetics for Neuraxial Administration in Obstetric Anesthesia and Analgesia

Cossu, A.P.; De Giudici, L.M.; Piras, D.; Mura, P.; Scanu, M.; Cossu, M.; Saba, M.; Finco, G.; Brazzi, L.

Obstetric Anesthesia Digest: June 2016 - Volume 36 - Issue 2 - p 69–70
doi: 10.1097/01.aoa.0000482602.26500.64
Editorials and Reviews

(Int J Obstet Anesth. 2015;24:237–246)

Neostigmine, an acetyl-cholinesterase inhibitor, has been used for both epidural and intrathecal anesthesia in obstetric patients. In order to quantify its benefits and/or adverse effects as an adjuvant in neuraxial anesthesia, the authors of this meta-analysis reviewed randomized, placebo-controlled studies in which neostigmine was administered in combination with local anesthetics or other adjuvants.

UOC Anesthesia and Intensive Care, AOU Sassari, Department of Surgical and Medical Sciences, University of Sassari, Sassari, Italy

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