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Fibrinogen Concentrates for Postpartum Hemorrhage?

Ickx, B.; Samama, C.M.

Obstetric Anesthesia Digest: March 2016 - Volume 36 - Issue 1 - p 35
doi: 10.1097/01.aoa.0000479512.73414.74
Mechanisms, Equipment, Hazards
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(Br J Anaesth. 2015;114(4):548–550)

Postpartum hemorrhage causes maternal morbidity during childbirth, and delay in treatment can complicate maternal recovery. Administering fibrinogen is thought to help reduce bleeding during postpartum hemorrhage and a plasma fibrinogen concentration <2 g/L is associated with an increased risk for heavier bleeding. However, there has been no solid evidence to support this assertion. In the study abstracted above, Wikkelsø et al investigated the benefit of fibrinogen concentrate infusion in a large multicenter randomized controlled clinical trial. Surprisingly, the authors found there was no benefit to using fibrinogen. However, some aspects of the trial need to be further considered.

Department of Anaesthesiology, Hospital Erasme, Brussels, Belgium

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