A 21-year old female scheduled for surgery with the presumptive diagnosis of ectopic pregnancy was premedicated with a metoclopramide (10mg)- glycopyrrolate (0.2 mg) combination. She had no prior medical or psychiatric history and had not taken any psychotropic medications. Within 10 minutes of premedication she became agitated, verbally abusive, refused surgery, and evidenced bizarre behavior in various parts of the hospital. She stated that she felt drugged and dizzy, felt compelled to act inappropriately, and was markedly dysphoric. Following 2 doses of benztropine (2 mg), she became calm with complete resolution of all her symptoms. 24 hours later she underwent uneventful general anesthesia for laparoscopy, although she was not premedicated.
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