GYNECOLOGY: GENETICSMechanism of Spindle Pole Organization and Instability in Human OocytesSo, Chun; Menelaou, Katerina; Uraji, Julia; Harasimov, Katarina; Steyer, Anna M.; Seres, K. Bianka; Bucevičius, Jonas; Lukinavičius, Gražvydas; Möbius, Wiebke; Sibold, Claus; Tandler-Schneider, Andreas; Eckel, Heike; Moltrecht, Rüdiger; Blayney, Martyn; Elder, Kay; Schuh, Melina Author Information Department of Meiosis, Max Planck Institute for Multidisciplinary Sciences, Göttingen, Germany (C.S., K.M., J.U., K.H., K.B.S., M.S.); Bourn Hall Clinic, Cambridge, United Kingdom (K.M., J.U., K.B.S., M.B., K.E.); Electron Microscopy Core Unit, Department of Neurogenetics (A.M.S., W.M.) and Chromatin Labeling and Imaging Group, Department of NanoBiophotonics (J.B., G.L.), Max Planck Institute for Multidisciplinary Sciences; Cluster of Excellence “Multiscale Bioimaging: from Molecular Machines to Networks of Excitable Cells” (MBExC), University of Göttingen (W.M., M.S.), Göttingen; Fertility Center Berlin, Berlin (C.S., A.T.-S.); and Kinderwunschzentrum Göttingen, Göttingen (H.E., R.M.), Germany Obstetrical & Gynecological Survey: May 2022 - Volume 77 - Issue 5 - p 278-280 doi: 10.1097/OGX.0000000000001038 Buy Metrics Abstract (Abstracted from Science 2022;375:eabj3944) Approximately 25% to 50% of human eggs are aneuploid, with even higher rates among older women. Aneuploidy is a leading cause of abnormal embryonic development resulting in miscarriage and genetic disorders. Copyright © 2022 Wolters Kluwer Health, Inc. All rights reserved.