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Universal Endometrial Cancer Tumor Typing

How Much Has Immunohistochemistry, Microsatellite Instability, and MLH1 Methylation Improved the Diagnosis of Lynch Syndrome Across the Population?

Kahn, Ryan M.; Gordhandas, Sushmita; Maddy, Brandon Paul; Nelson, Becky Baltich; Askin, Gulce; Christos, Paul J.; Caputo, Thomas A.; Chapman-Davis, Eloise; Holcomb, Kevin; Frey, Melissa K.

Obstetrical & Gynecological Survey: November 2019 - Volume 74 - Issue 11 - p 652–654
doi: 10.1097/OGX.0000000000000736
GYNECOLOGY: GYNECOLOGIC ONCOLOGY
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(Abstracted from Cancer 2019;125(18):3172–3183)

Lynch syndrome caused by germline mutations in several DNA mismatch repair (MMR) proteins is the most common cause of hereditary and endometrial cancers. Lynch syndrome accounts for approximately 2% to 3% of all endometrial cancers, although the lifetime risk of endometrial cancer for patients with Lynch syndrome varies depending on the specific mutation.

Departments of Obstetrics and Gynecology (R.M.K., S.G., B.P.M.) and Information Technologies and Services (B.B.N.); Clinical and Translational Science Center, Department of Biostatistics and Epidemiology (G.A., P.J.C.); and Division of Gynecologic Oncology, Department of Obstetrics and Gynecology (T.A.C., E.C.-D., K.H., M.K.F.), Weill Cornell Medical College, New York, NY

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