(Abstracted from Ultrasound Obstet Gynecol 2019;53:734–742)
Cell-free DNA (cfDNA) analysis of maternal blood is useful and effective when screening for trisomies 21, 18, and 13 in singleton pregnancies. However, in twin pregnancies, data on cfDNA tests are much more limited: in a previous literature review and meta-analysis, there were only 5 prospective studies.
Fetal Medicine Research Institute, King's College Hospital, London, United Kingdom (M.M.G., S.G., L.K., K.H.N.); Obstetrics and Gynecology Department, Hospital Universitario de Torrejón, Torrejón de Ardoz (M.M.G.); School of Health Sciences, Universidad Francisco de Vitoria, Pozuelo de Alarcón (M.M.G.), Madrid, Spain; Department of Fetal Medicine, Medway Maritime Hospital, Gillingham, United Kingdom (S.G., R.A.); Department of Obstetrics and Gynecology, University Hospital Brugmann, Université Libre de Bruxelles, Brussels, Belgium (J.J.); Institute of Medical Sciences, Canterbury Christ Church University, Chatham, United Kingdom (R.A.); Department of Preventive Medicine and Public Health, Hospital Príncipe de Asturias, Alcalá de Henares (M.N.P.); and CIBER Epidemiology and Public Health (CIBERESP) (M.N.P.), Madrid, Spain