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The Vaginal Microbiome as a Predictor for Outcome of In Vitro Fertilization With or Without Intracytoplasmic Sperm Injection

A Prospective Study

Koedooder, R.; Singer, M.; Schoenmakers, S.; Savelkoul, P. H. M.; Morré, S. A.; de Jonge, J. D.; Poort, L.; Cuypers, W. J. S. S.; Beckers, N. G. M.; Broekmans, F. J. M.; Cohlen, B. J.; den Hartog, J. E.; Fleischer, K.; Lambalk, C. B.; Smeenk, J. M. J. S.; Budding, A. E.; Laven, J. S. E.

Obstetrical & Gynecological Survey: October 2019 - Volume 74 - Issue 10 - p 596–597
doi: 10.1097/01.ogx.0000584064.03901.29
GYNECOLOGY: INFERTILITY/REPRODUCTIVE TECHNOLOGIES
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(Abstracted from Human Reproduction 2019;34(6):1042–1054)

Nearly one third of all subfertility causes remain unexplained. In addition, assisted-reproductive technologies (ARTs) such as IVF-ICSI are invasive and only 25% to 35% of women become pregnant after the first embryo transfer (ET).

Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynaecology, Erasmus University Medical Center, Rotterdam (R.K., J.S.E.L.); Laboratory of Immunogenetics, Department of Medical Microbiology and Infection Control, Amsterdam University Medical Center, Amsterdam (M.S., P.H.M.S., S.A.M., A.E.B.); Division Obstetrics and Fetal Medicine, Department of Obstetrics and Gynaecology, Erasmus University Medical Center, Rotterdam (S.S.); Department of Medical Microbiology, School of Nutrition and Translational Research in Metabolism, Maastricht University Medical Center (P.H.M.S.); Institute of Public Health Genomics, Department of Genetics and Cell Biology, Research Institute GROW, Faculty of Health, Medicine and Life Sciences, University of Maastricht (S.A.M.), Maastricht; ARTPred B.V., Hoofddorp (J.D.d.J.); IS-Diagnostics Ltd, Department of Medical Microbiology and Infection Control, Amsterdam University Medical Center, Amsterdam (L.P., A.E.B.), the Netherlands; Dutch Division, MVZ VivaNeo Kinderwunschzentrum Düsseldorf GmbH, Düsseldorf, Germany (W.J.S.S.C.); VivaNeo Medisch Centrum Kinderwens, Leiderdorp (N.G.M.B.); Division of Reproductive Medicine, Department of Obstetrics and Gynaecology, University Medical Center Utrecht, Utrecht (F.J.M.B.); Isala Voortplantingscentrum, Isala Kliniek, Zwolle (B.J.C.); Division of Reproductive Medicine, Department of Obstetrics and Gynaecology, Maastricht Universitair Medisch Centrum+, Maastricht (J.E.d.H.); Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynaecology, Radboud University Medical Center, Nijmegen (K.F.); Division of Reproductive Medicine, Department of Obstetrics and Gynaecology, Amsterdam University Medical Center, Amsterdam (C.B.L.); and Division of Reproductive Medicine, Department of Obstetrics and Gynaecology, Tilburg (J.M.J.S.S.), the Netherlands

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