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Dual Trigger With Gonadotropin Releasing Hormone Agonist and Human Chorionic Gonadotropin Significantly Improves Live Birth Rate for Women With Diminished Ovarian Reserve

Lin, Ming-Huei; Wu, Frank Shao-Ying; Hwu, Yuh-Ming; Lee, Robert Kuo-Kuang; Li, Ryh-Sheng; Li, Sheng-Hsiang

Obstetrical & Gynecological Survey: September 2019 - Volume 74 - Issue 9 - p 534–535
doi: 10.1097/OGX.0000000000000723
GYNECOLOGY: INFERTILITY/REPRODUCTIVE TECHNOLOGIES
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(Abstracted from Reprod Biol Endocrinol 2019;17:7)

As the prevalence of fertility treatment increases, research into managing “diminished ovarian reserve” (DOR) remains a challenge. A “dual trigger” consisting of a gonadotropin hormone–releasing hormone agonist (GnRH-a) in combination with a reduced dose of human chorionic gonadotropin (hCG) showed robust evidence of increased pregnancy and live birth rate without ovarian hyperstimulation in in vitro fertilization (IVF) cycles for high responders.

Departments of Obstetrics and Gynecology (M.-H.L., Y.-M.H., R.K-K.L., R.-S.L.) and Medical Research, Mackay Memorial Hospital (M.-H.L., Y.-M.H., R.K.-K.L., S.-H.,L.); and Mackay Junior College of Medicine, Nursing, and Management (M.-H.L., Y.-M.H., S.-H.,L.), Taipei; Mackay Medical College, New Taipei City (M.-H.L., Y.-M.H.); and IHMED Fertility Clinic (F.S.-Y.); Taipei City Hospital, Heping-Fuyou Branch (F.S.-Y.); and Department of Obstetrics and Gynecology, Taipei Medical University (R.K.-K.L.), Taipei, Taiwan

Received: 9 November 2018 Accepted: 27 December 2018.

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