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Maternal Telomere Length Is Shorter in Intrauterine Growth Restriction Versus Uncomplicated Pregnancies, But Not in the Offspring or in IVF-Conceived Newborns

Perales-Puchalt, Alfredo; Soberón, Nora; Monterde, Mercedes; Hervas-Marin, David; Foronda, Miguel; Desantes, Domingo; Soler, Inmaculada; Perales-Marin, Alfredo; Pellicer, Antonio; Blasco, Maria A.

Obstetrical & Gynecological Survey: August 2019 - Volume 74 - Issue 8 - p 476–477
doi: 10.1097/OGX.0000000000000712
GYNECOLOGY: INFERTILITY/REPRODUCTIVE TECHNOLOGIES
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(Abstracted from Reprod Biomed Online 2019;38(4):606–612)

Telomeres are protective nucleoprotein structures found at the end of chromosomes that progressively shorten with each round of DNA replication during cell division. Telomere shortening is associated with physiological aging, and short telomeres have been found to be an early indicator of cardiovascular disease.

Departamento de Obstetricia y Ginecología, Hospital Universitari i Politecnic La Fe, Valencia (A.P.-P., D.D., I.S., A.P.-M., A.P.); Telomere and Telomerase Group, Molecular Oncology Program, Spanish National Cancer Research Centre (CNIO), Madrid (N.S., M.F., M.A.B.); Instituto de Investigación Sanitaria La Fe, Grupo Acreditado de Investigación en Medicina Reproductiva, Hospital Universitari I Politècnic La Fe (M.M., A.P.); Instituto de Investigación Sanitaria La Fe, Departamento de Bioestadística, Hospital Universitari I Politècnic La Fe (D.H.-M.); and Instituto Valenciano de Infertilidad (IVI), Plaça de la Policia Local (A.P.), Valencia, Spain

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