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Endometrial Scratching for Infertile Women Undergoing a First Embryo Transfer

A Systematic Review and Meta-analysis of Published and Unpublished Data From Randomized Controlled Trials

Vitagliano, Amerigo; Andrisani, Alessandra; Alviggi, Carlo; Vitale, Salvatore Giovanni; Valenti, Gaetano; Sapia, Fabrizio; Favilli, Alessandro; Martins, Wellington P.; Raine-Ferring, Nick; Polanski, Lukasz; Ambrosini, Guido

Obstetrical & Gynecological Survey: June 2019 - Volume 74 - Issue 6 - p 347–348
doi: 10.1097/OGX.0000000000000688

(Abstracted from Fertil Steril 2019;111(4):734–746.e2)

Despite significant improvements in assisted reproductive technology (ART), clinical pregnancy rates (CPRs) and live-birth rates (LBRs) following in vitro fertilization and embryonic transfer (ET) remain between 30% and 40% and between 20% and 30% per ET, respectively. Endometrial scratch injury (ESI) is a technique that involves the use of common biopsy devices to damage the endometrium in order to increase its receptiveness to embryonic implantation in women undergoing ART.

Unit of Gynecology and Obstetrics, Department of Women and Children's Health, University of Padua, Padua (A.V., A.A., G.A.); Department of Neuroscience, Reproductive Science, and Odontostomatology, University of Naples Federico II, Naples (C.A.); Department of General Surgery and Medical Surgical Specialties, University of Catania, Catania (S.G.V., G.V., F.S.); Section of Obstetrics and Gynecology, Department of Surgical and Biomedical Sciences, Santa Maria Della Misericordia Hospital, University of Perugia, Perugia (A.F.), Italy; SEMEAR Fertilidade, São Paolo, Brazil (W.P.M.); Division of Obstetrics and Gynaecology, Faculty of Medicine & Health Sciences, University of Nottingham (N.R.-F., L.P.); and NURTURE Fertility (L.P.), Nottingham, United Kingdom

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