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Association of Maternal First-Trimester Ondansetron Use With Cardiac Malformations and Oral Clefts in Offspring

Huybrechts, Krista F.; Hernández-Díaz, Sonia; Straub, Loreen; Gray, Kathryn J.; Zhu, Yanmin; Patorno, Elisabetta; Desai, Rishi J.; Mogun, Helen; Bateman, Brian T.

Obstetrical & Gynecological Survey: May 2019 - Volume 74 - Issue 5 - p 257–259
doi: 10.1097/OGX.0000000000000675

(Abstracted from JAMA 2018;320(23):2429–2437)

Nausea and vomiting is common in pregnancy and is reported to occur in up to 80% of women. About one-third of women with nausea and vomiting during pregnancy have symptoms that are clinically significant, and a small percentage develop hyperemesis gravidarum, which is the most common indication for hospital admission during the first part of pregnancy.

Division of Pharmacoepidemiology and Pharmacoeconomics, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School (K.F.H., L.S., Y.Z., E.P., R.J.D., H.M., B.T.B.); Department of Epidemiology, Harvard T. H. Chan School of Public Health (S.H.-D.); and Division of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology (K.J.G.), and Department of Anesthesiology, Perioperative, and Pain Medicine (B.T.B.), Brigham and Women's Hospital and Harvard Medical School, Boston, MA

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