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Mismatch Repair Deficiency Identifies Patients With High-Intermediate–Risk (HIR) Endometrioid Endometrial Cancer at the Highest Risk of Recurrence

A Prognostic Biomarker

Backes, Floor J.; Haag, Jennifer; Cosgrove, Casey M.; Suarez, Adrian; Cohn, David E.; Goodfellow, Paul J.

Obstetrical & Gynecological Survey: April 2019 - Volume 74 - Issue 4 - p 215–216
doi: 10.1097/OGX.0000000000000668
GYNECOLOGY: GYNECOLOGIC ONCOLOGY
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(Abstracted from Cancer 2019;125:398–405)

More than 70% of patients diagnosed with endometrial cancer (EC) are stage I, and such early-stage disease has good outcomes, with reported 5-year survival rates of 90%. However, a small subgroup has been identified—the so-called high-intermediate–risk (HIR) EC—which has relatively high local and distant recurrence rates, resulting in poor survival.

Divisions of Gynecologic Oncology (F.J.B., J.H., C.M.C., D.E.C., P.J.G.) and Pathology (A.S.), Ohio State University Comprehensive Cancer Center, Columbus, OH

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