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Pregnancy Outcome of Autosomal Aneuploidies Other Than Common Trisomies Detected by Noninvasive Prenatal Testing in Routine Clinical Practice

Wan, Junhui; Li, Ru; Zhang, Yongling; Jing, Xiangyi; Yu, Qiuxia; Li, Fatao; Li, Yan; Zhang, Lina; Yi, Cuixing; Li, Jian; Li, Dongzhi; Liao, Can

Obstetrical & Gynecological Survey: March 2019 - Volume 74 - Issue 3 - p 141–143
doi: 10.1097/01.ogx.0000554052.72162.32
OBSTETRICS: GENETICS
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(Abstracted from Prenat Diagn 2018;38:849–857)

The discovery of cell-free fetal DNA in maternal plasma and the invention of massively parallel sequencing have made noninvasive prenatal testing (NIPT) for fetal common aneuploidies (trisomies 13, 18, and 21) a clinical reality. Noninvasive prenatal testing has been recommended as a first-tier or second-tier screening test for common fetal trisomies, with lower false-positive rates and higher positive predictive values than serum biochemical screening.

Department of Prenatal Diagnostic Center, Guangzhou Women and Children's Medical Centre, Guangzhou Medical University, Guangzhou, People's Republic of China

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