(Abstracted from Science 2018;362:356–360)
Studies have shown that mouse pluripotent stem cells (PSCs) can be induced into primordial germ cell–like cells (hPGCLCs), which, following transplantation under appropriate conditions, can contribute to the development of gametes capable of developing into fertile offspring. Human in vitro gametogenesis from PSCs has long-reaching implications in reproductive medicine but has not yet been achieved.
Department of Anatomy and Cell Biology, Graduate School of Medicine, Kyoto University (C.Y., K. Sasaki, Y.Y., Y.K., T.N., I.O., S.Y., Y.M., Y.I., M.S.); Japan Science and Technology Agency (JST), Exploratory Research for Advanced Technology (ERATO) (C.Y., K. Sasaki, Y.Y., Y.K., T.N., I.O., S.Y., Y.M., Y.I., M.S.); Institute for Integrated Cell-Material Sciences, Kyoto University (Y.K., T.Y., M.S.); Center for iPS Cell Research and Application, Kyoto University (Y.K., S.Y., T.Y., M.S.), Kyoto; Division of Epigenomics, Medical Institute of Bioregulation, and Epigenome Network Research Center, Kyushu University (K. Shirane, H.S.); Graduate School of Medical Sciences, Kyushu University (K. Shirane, H.S.), Fukuoka; and Agency for Medical Research and Development-Core Research for Evolutional Science and Technology (AMED-CREST), AMED, Tokyo (T.Y.), Japan