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Donor Spermatogenesis in De Novo Formed Seminiferous Tubules From Transplanted Testicular Cells in Rhesus Monkey Testis

Shetty, Gunapala; Mitchell, Jennifer M.; Lam, Truong Nguyen Anh; Wu, Zhuang; Zhang, Jie; Hill, Lorraine; Tailor, Ramesh C.; Peters, Karen A.; Penedo, Maria Cecilia; Orwig, Kyle E.; Meistrich, Marvin L.

Obstetrical & Gynecological Survey: March 2019 - Volume 74 - Issue 3 - p 159–160
doi: 10.1097/01.ogx.0000554462.39085.10
GYNECOLOGY: INFERTILITY/REPRODUCTIVE TECHNOLOGIES
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(Abstracted from Hum Reprod 2018;33:2249–2255)

Cytotoxic cancer treatments, including chemotherapy and radiotherapy, cause damage to spermatogenic stem cells (SSCs), jeopardizing the fertility of young men of reproductive age. One potential method for future production of sperm in this population is SSC transplantation.

Departments of Experimental Radiation Oncology (G.S., T.N.A.L., Z.W., J.Z., M.L.M.), Veterinary Medicine and Surgery (J.M.M., L.H.), and Radiation Physics (R.C.T.), University of Texas MD Anderson Cancer Center, Houston, TX; Veterinary Genetics Laboratory, University of California, Davis, CA (M.C.P.); and Department of Obstetrics, Gynecology and Reproductive Sciences, University of Pittsburgh School of Medicine, Magee-Womens Research Institute, Pittsburgh, PA (K.A.P., K.E.O.)

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