(Abstracted from JAMA 2018;320(14):1464–1470)
Pertussis incidence is highest in infants too young to have completed their primary immunization series (6 months or younger), who are also at the highest risk of developing life-threatening complications. In high-income countries, pertussis-related mortality occurs predominantly in infants 3 months or younger.
Infectious Disease Section, Department of Pediatrics (C.M.H., M.A.R., C.J.B.), Department of Obstetrics and Gynecology (L.S.S., H.S.-H.), and Department of Statistics (E.O.B.S., H.S.-H.), Baylor College of Medicine, Houston, TX; Pertussis and Diphtheria Laboratory, Centers for Disease Control and Prevention, Atlanta, GA (M.H.M., M.D.M.); Department of Molecular Virology and Microbiology, Baylor College of Medicine (C.J.B.); and Department of Pediatrics, The University of Texas Health Science Center at Houston (C.J.B.), Houston, TX