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Association Between Third-Trimester Tdap Immunization and Neonatal Pertussis Antibody Concentration

Healy, C. Mary; Rench, Marcia A.; Swaim, Laurie S.; O'Brian Smith, E.; Sangi-Haghpeykar, Haleh; Mathis, Marsenia H.; Martin, Monte D.; Baker, Carol J.

Obstetrical & Gynecological Survey: March 2019 - Volume 74 - Issue 3 - p 143–145
doi: 10.1097/OGX.0000000000000658
OBSTETRICS: INFECTIOUS DISEASE
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(Abstracted from JAMA 2018;320(14):1464–1470)

Pertussis incidence is highest in infants too young to have completed their primary immunization series (6 months or younger), who are also at the highest risk of developing life-threatening complications. In high-income countries, pertussis-related mortality occurs predominantly in infants 3 months or younger.

Infectious Disease Section, Department of Pediatrics (C.M.H., M.A.R., C.J.B.), Department of Obstetrics and Gynecology (L.S.S., H.S.-H.), and Department of Statistics (E.O.B.S., H.S.-H.), Baylor College of Medicine, Houston, TX; Pertussis and Diphtheria Laboratory, Centers for Disease Control and Prevention, Atlanta, GA (M.H.M., M.D.M.); Department of Molecular Virology and Microbiology, Baylor College of Medicine (C.J.B.); and Department of Pediatrics, The University of Texas Health Science Center at Houston (C.J.B.), Houston, TX

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