(Abstracted from BMJ 2018;362:k2644)
Assisted reproductive therapy such as exposure of women to supraphysiological levels of estradiol, exogenous gonadotropins, and multiple ovarian punctures are suspected to incur an increased risk of cancer. Studies investigating the carcinogenic effects of these exposures are largely inconsistent.
UCL Great Ormond Street Institute of Child Health (C.L.W., B.J.B., A.G.S.); Institute of Cancer Research (M.E.J., A.J.S.); Institute for Women’s Health, University College London Hospitals (M.C.D., I.J.), London, United Kingdom; University of New South Wales, Sydney, Australia (I.J.); and National Perinatal Epidemiology Unit (K.J.B.), and Nuffield Department of Obstetrics and Gynaecology (M.F.G.M.), University of Oxford, Oxford, United Kingdom