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Effect of High Dose Folic Acid Supplementation in Pregnancy on Pre-eclampsia (FACT)

Double Blind, Phase III, Randomised Controlled, International, Multicentre Trial

Wen, Shi Wu; White, Ruth Rennicks; Rybak, Natalie; Gaudet, Laura M.; Robson, Stephen; Hague, William; Simms-Stewart, Donnette; Carroli, Guillermo; Smith, Graeme; Fraser, William D.; Wells, George; Davidge, Sandra T.; Kingdom, John; Coyle, Doug; Fergusson, Dean; Corsi, Daniel J.; Champagne, Josee; Sabri, Elham; Ramsay, Tim; Mol, Ben Willem J.; Oudijk, Martijn A.; Walker, Mark C. on behalf of the FACT Collaborating Group

Obstetrical & Gynecological Survey: February 2019 - Volume 74 - Issue 2 - p 68–70
doi: 10.1097/01.ogx.0000553100.78470.9a

(Abstracted from BMJ 2018;362:k3478)

Preeclampsia is a serious medical condition, affecting approximately 3% to 5% of pregnancies, accounting for more than 35,000 maternal deaths annually worldwide and an important factor in maternal morbidity. Preeclampsia affects multiple organ systems and leads to an increased risk of other severe maternal and neonatal complications in pregnancy.

OMNI Research Group, Clinical Epidemiology Program, Ottawa Hospital Research Institute (S.W.W., R.R.W., N.R., L.M.G., D.J.C., M.C.W.); School of Epidemiology, Public Health and Preventive Medicine, University of Ottawa (S.W.W., L.M.G., G.W., D.C., M.C.W.); Department of Obstetrics, Gynecology & Newborn Care, University of Ottawa (S.W.W., L.M.G., M.C.W.), Ottawa, Ontario, Canada; Institute of Cellular Medicine, The Medical School, Newcastle University, Newcastle upon Tyne, United Kingdom (S.R.); Obstetric Medicine, Robinson Research Institute, University of Adelaide (W.H., B.W.J.M.); Women's and Children's Hospital (W.H.), Adelaide, South Australia, Australia; Department of Obstetrics and Gynaecology, Faculty of Medical Sciences, The University of the West Indies, Mona, Kingston, Jamaica (D.S.-S.); Centro Rosarino de Estudios Perinatales (CREP), Rosario, Santa Fé, Argentina (G.C.); Queen's Perinatal Research Unit, Kingston General Hospital, Department of Obstetrics and Gynecology, Queens University, Kingston, Ontario (G.S.); Mother & Child Axis, Centre de Recherche du Centre Hospitalier Universitaire de Sherbrooke (W.D.F.); Centre de Recherche, Universite de Sherbrooke (W.D.F.); Department of Obstetrics and Gynecology, Faculty of Medicine and Health Sciences, Centre de Recherche du CHUS, University of Sherbrooke (W.D.F.), Sherbrooke, Quebec; Cardiovascular Research Methods Centre, University of Ottawa Heart Institute (G.W.); Department of Medicine, University of Ottawa (G.W.); Clinical Epidemiology Program, Ottawa Hospital Research Institute (G.W., D.F., J.C., E.S., T.R.), Ottawa, Ontario; Women and Children's Health Research Institute (S.T.D.) and Departments of Obstetrics and Gynecology (S.T.D.) and Physiology (S.T.D.), University of Alberta, Edmonton, Alberta; Maternal-Fetal Medicine Division, Department of Obstetrics and Gynecology, Mount Sinai Hospital, University of Toronto, Toronto, Ontario (J.K.); Departments of Medicine, School of Epidemiology, Public Health and Preventive Medicine, University of Ottawa, Ottawa, Ontario (D.F., T.R.), Canada; Department of Obstetrics and Gynaecology, Monash University, Clayton, Victoria, Australia (B.W.J.M.); Department of Obstetrics, University Medical Center, Utrecht, Utrecht (M.A.O.); and Department of Obstetrics, Academic Medical Center, Amsterdam (M.A.O.), the Netherlands

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