(Abstracted from Pediatrics 2018;142(1):e20180522)
Antenatal corticosteroid therapy is one of the most effective interventions for preterm birth, resulting in rapid maturation of fetal organ systems. The Australasian Collaborative Trial of Repeat Doses of Steroids (ACTORDS) revealed that neonatal benefit is greatest when antenatal corticosteroids are administered in repeat doses, which can be used to reduce the incidence and severity of preterm lung disease and other serious neonatal morbidity, with absolute benefits similar to that of an initial course of antenatal corticosteroids.
Liggins Institute, University of Auckland, Auckland, New Zealand (R.D.C., J.E.H., C.A.C., W.S.C., M.R.B., S.R.D., C.J.D.M.); Department of Obstetrics and Gynecology, School of Medicine, The University of Adelaide, Adelaide, Australia (C.A.C.); A Better Start, National Science Challenge (W.S.C.); Newborn Services, National Women's Health, Auckland City Hospital (M.R.B.); Children's Emergency Department, Starship Children's Health (S.R.D.); Department of Pediatrics, Child and Youth Health, University of Auckland (C.J.D.M.); and Kidz First Neonatal Care, Counties Manukau Health (C.J.D.M.), Auckland, New Zealand