(Abstracted from BMJ 2018;362:k2739)
Placental vascular disease is thought to arise within the temporary interface of the trophoblast and endometrial decidua, resulting in adverse outcomes for mother and fetus, including preeclampsia, placental abruption, poor fetal growth, and preterm birth. Some risk factors for placental vascular disease, including for preeclampsia, are the same as those for cardiovascular disease.
Departments of Medicine, Health Policy Management and Evaluation, and Obstetrics and Gynecology, St Michael's Hospital (J.G.R.); Institute for Clinical Evaluative Sciences, University of Toronto (J.G.R., A.L.P.); Genetics Program, North York General Hospital (T.H.); Institute of Health Policy, Management and Evaluation (T.H., W.S.M., E.C.), and Department of Paediatrics (W.S.M.), University of Toronto; and Department of Pediatrics, Hospital for Sick Children (E.C.), Toronto, Ontario, Canada