(Abstracted from BJOG 2018;125:848–855)
Noninvasive prenatal testing (NIPT) involves the analysis of cell-free DNA fragments in maternal serum. During pregnancy, cell-free DNA consists of both maternal fragments, primarily from hematopoietic cells, and fetal fragments, released from trophoblasts during apoptosis.
Sydney Medical School, University of Sydney (N.C.); Sydney Ultrasound for Women (M.-E.S., R.S., A.M.), Sydney; Monash Ultrasound for Women, Melbourne (F.d.S.C.); Department of Obstetrics and Gynaecology, Monash University, Melbourne (F.d.S.C.); and Discipline of Obstetrics, Gynaecology and Neonatology, Faculty of Medicine, University of Sydney, Sydney (A.M.), Australia