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Implications of Failure to Achieve a Result From Prenatal Maternal Serum Cell-Free DNA Testing

A Historical Cohort Study

Chan, N.; Smet, M.-E.; Sandow, R.; da Silva Costa, F.; McLennan, A.

Obstetrical & Gynecological Survey: November 2018 - Volume 73 - Issue 11 - p 611–613
doi: 10.1097/01.ogx.0000547740.99438.d9
OBSTETRICS: FETAL DIAGNOSIS AND THERAPY

(Abstracted from BJOG 2018;125:848–855)

Noninvasive prenatal testing (NIPT) involves the analysis of cell-free DNA fragments in maternal serum. During pregnancy, cell-free DNA consists of both maternal fragments, primarily from hematopoietic cells, and fetal fragments, released from trophoblasts during apoptosis.

Sydney Medical School, University of Sydney (N.C.); Sydney Ultrasound for Women (M.-E.S., R.S., A.M.), Sydney; Monash Ultrasound for Women, Melbourne (F.d.S.C.); Department of Obstetrics and Gynaecology, Monash University, Melbourne (F.d.S.C.); and Discipline of Obstetrics, Gynaecology and Neonatology, Faculty of Medicine, University of Sydney, Sydney (A.M.), Australia

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