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Association of Histologic Chorioamnionitis With Perinatal Brain Injury and Early Childhood Neurodevelopmental Outcomes Among Preterm Neonates

Bierstone, Daniel; Wagenaar, Nienke; Gano, Dawn L.; Guo, Ting; Georgio, Gregory; Groenendaal, Floris; de Vries, Linda S.; Varghese, Jojy; Glass, Hannah C.; Chung, Catherine; Terry, Jefferson; Rijpert, Maarten; Grunau, Ruth E.; Synnes, Anne; Barkovich, A. James; Ferriero, Donna M.; Benders, Manon; Chau, Vann; Miller, Steven P.

Obstetrical & Gynecological Survey: November 2018 - Volume 73 - Issue 11 - p 621–623
doi: 10.1097/01.ogx.0000549830.07599.6f

(Abstracted from JAMA Pediatr 2018;172(6):534–541)

Acute chorioamnionitis refers to the neutrophilic inflammation of the placental tissues thought to result from an ascending bacterial infection. It is considered a major factor associated with preterm birth and has been estimated to occur in 40% to 80% of preterm deliveries.

Department of Paediatrics, The Hospital for Sick Children and University of Toronto, Toronto (D.B., T.G., J.V., V.C., S.P.M.); Department of Paediatrics, Children's Hospital of Eastern Ontario, Ottawa (D.B.), Ontario, Canada; Department of Neonatology, Wilhelmina Children's Hospital, University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands (N.W., F.G., L.S.d.V., M.R., M.B.); Department of Pediatrics (D.L.G., H.C.G., D.M.F.) and Department of Neurology (D.L.G., H.C.G., D.M.F.), UCSF (University of California, San Francisco) Benioff Children's Hospital, San Francisco, CA; Department of Pediatrics, University of British Columbia (G.G., R.E.G., A.S., S.P.M.); Brain, Behaviour, and Development, BC Children's Hospital Research Institute (G.G., R.E.G., A.S., S.P.M.), Vancouver, British Columbia, Canada; Department of Epidemiology and Biostatistics, UCSF Benioff Children's Hospital, San Francisco, CA (H.C.G.); Department of Paediatric Laboratory Medicine, The Hospital for Sick Children, University of Toronto, Toronto, Ontario (C.C.); Department of Anatomical Pathology, BC Women's and Children's Hospital and Health Centre (J.T.); Department of Pathology and Laboratory Medicine, University of British Columbia (J.T.), Vanouver, British Columbia, Canada; and Department of Radiology, UCSF Benioff Children's Hospital, San Francisco, CA (A.J.B.)

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