(Abstracted from Am J Obstet Gynecol 2018;218:483–489)
Impaired placentation in the first 16 weeks of pregnancy is associated with increased risk of subsequent development of preeclampsia, birth of small-for-gestational-age (SGA) neonates, and placental abruption. Previous studies reported that prophylactic use of aspirin reduces the risk of preeclampsia and SGA neonates with no significant effect on placental abruption.
Harris Birthright Research Centre of Fetal Medicine, Fetal Medicine Research Institute, King's College Hospital, London, United Kingdom (S.R., K.H.N.); and Department of Obstetrics and Gynecology and Department of Social and Preventive Medicine, Faculty of Medicine, Université Laval, Quebec City, Quebec, Canada (E.B.)